Brief history：
Ms. Hu, born in 1986, underwent laparoscopic left ovarian cyst dissection in a local hospital due to ultrasound finding of left ovarian crown cyst in 2011. Regular menstrual cycle, 28 days, menstrual period 7 days, moderate amount of menstruation, no dysmenorrhea. Since 2016, the menstrual cycle has been extended to 1-3 months and treated with traditional Chinese medicine. In February 2017, FSH: 60.87iu/l, AMH: 0.02. In other hospital diagnosis: premature ovarian failure. During the period from 2017 to September 2018, Regulating menstrual period by fenmotone (from white / grey to red / yellow tablets). The semen of the male was normal.

History of assisted pregnancy in our hospital:

◎First visit  to our hospital in September 2018
◎From September 2018 to December 2019, clomiphene was given, MPA promoted ovulation, no basal follicle, and FSH ranged from 20 to 40 IU / L.
◎In January 2019, there was basic follicle by remote monitoring. One follicle developed and one MII was obtained. IVF fertilization and 3PN (abnormal fertilized) were obtained.
◎OC + clomiphene was given from January to may, 2019. There was no basal follicle. FSH was between 20-50iu / L.
◎In May 2019，On the 19th day of the natural cycle by remote monitoring, the follicle diameter was 14.5mm, LH: 28.2iu/l. On the evening of the 19th day, 0.1mg of Decapeptyl was given, and one egg was obtained in 34 hours. ICSI was fertilized. The endometrial trigger day was 10.5A, and one D2 fresh embryo (4cii) was transfered . Successful pregnant, intrauterine singleton. The pregnancy process was smooth.
◎On February 6, 2020, a healthy female infant was delivered by cesarean section, weighing 3350g.

comment：

1.Ms. Hu, FSH is high, AMH is low, premature ovarian failure. In this case, the natural cycle protocal was used. Although only one egg was obtained, the utilization of egg was high. The patient was 32 years old. Although the number of eggs was small, the quality of egg was better. Therefore, the earlier the patients with low ovarian reserve were treated with assisted reproductive therapy, the better the effect was.
2.Individualized treatment plan, the natural cycle has the possibility of early ovulation, actively give it early egg collection.
3.If endometrial morphology is good, fresh D2 embryo transfer can be tried.
4.Don't give up every chance of pregnancy. Mutual trust between doctors and patients (the patient was once suggested to donate eggs. After communicating with the attending doctor, the patient was given a chance to be a mother.